Body iron is a contributor to oxidative damage of DNA.
Free Radic Res
; 41(3): 324-8, 2007 Mar.
Article
em En
| MEDLINE
| ID: mdl-17364961
ABSTRACT
The transition metal iron is catalytically highly active in vitro, and not surprisingly, body iron has been suggested to promote oxidative stress in vivo. In the current analysis we studied the association of serum ferritin concentration and serum soluble transferrin receptor concentration with daily urinary 8-hydroxydeoxyguanosine excretion, a marker of oxidative stress, in 48 mildly dyslipidemic men in East Finland. In multivariate linear regression analyses allowing for age, smoking, body mass index and physical exercise, serum ferritin concentration predicted the excretion rate at B = 0.17 (95% CI 0.08-0.26, P = 0.001), and serum soluble transferrin receptor to ferritin concentration ratio (TfR/ferritin) predicted the excretion rate at B = - 0.13 (95% CI - 0.21 to - 0.05, P = 0.002). Our data suggest that body iron contributes to excess oxidative stress already at non-iron overload concentrations in these subjects.
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Base de dados:
MEDLINE
Assunto principal:
Dano ao DNA
/
Receptores da Transferrina
/
Estresse Oxidativo
/
Ferritinas
/
Hipercolesterolemia
/
Ferro
Limite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article