Preparation, characterization, and optimization of pancreas-targeted 5-Fu loaded magnetic bovine serum albumin microspheres.
J Drug Target
; 15(2): 140-5, 2007 Feb.
Article
em En
| MEDLINE
| ID: mdl-17365285
ABSTRACT
The magnetic bovine serum albumin (BSA) microspheres (MS) were prepared by emulsification/solidification method. In this experiment, two kinds of magnetic MS, e.g. BSA MS and PEG-incorporated BSA microspheres (PMS) were prepared. The obtained MS were characterized by Malvern laser particle sizer and scanning electron microscopy (SEM). The obtained MS were spherical and about 1.3 microm in size. The magnetic responsivity and in vitro release behavior of these MS were studied in detail. The in vivo distribution and targeting delivery of 5-fluorouracil (5-Fu) magnetic MS after artery administration were studied in rat. The results showed that PMS could efficiently delivery 5-Fu to the targeted site compared with BSA MS without PEG MS and free drug.
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Base de dados:
MEDLINE
Assunto principal:
Pâncreas
/
Soroalbumina Bovina
/
Fluoruracila
Limite:
Animals
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article