Impact of maternal HIV coinfection on the vertical transmission of hepatitis C virus: a meta-analysis.
Clin Infect Dis
; 44(8): 1123-31, 2007 Apr 15.
Article
em En
| MEDLINE
| ID: mdl-17366462
ABSTRACT
BACKGROUND:
Observational studies suggest that maternal human immunodeficiency virus (HIV)-hepatitis C virus (HCV) coinfection is associated with increased odds of vertical HCV transmission. We performed a meta-analysis to summarize current evidence.METHODS:
We systematically searched for relevant articles published during the period from January 1992 through July 2006 and independently abstracted articles that met our inclusion criteria. Under a random effects model, we calculated the pooled odds ratio for vertical HCV transmission according to maternal HIV-HCV coinfection status and performed sensitivity analyses.RESULTS:
Ten articles met our inclusion criteria. Study quality varied widely, and study estimates displayed high statistical heterogeneity. Restriction of the analysis to studies that included >50 HIV-HCV-coinfected women provided our most reliable estimate maternal HIV-HCV coinfection increases the odds of vertical HCV transmission by approximately 90% (odds ratio, 1.9; 95% confidence interval, 1.36-2.67), compared with maternal HCV infection alone. When we restricted analyses to HIV-infected mothers with HCV viremia, the odds of vertical HCV transmission were 2.82-fold (95% confidence interval, 1.17-fold to 6.81-fold) greater than the odds for HIV-infected mothers without HCV viremia.CONCLUSIONS:
HIV-HCV-coinfected women have significantly higher odds of transmitting HCV to their infants than do women who are infected with HCV alone.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Complicações Infecciosas na Gravidez
/
Infecções por HIV
/
Hepatite C
/
Transmissão Vertical de Doenças Infecciosas
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Systematic_reviews
Limite:
Female
/
Humans
/
Infant
/
Pregnancy
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article