Involvement of galanin in nociceptive regulation in the arcuate nucleus of hypothalamus in rats with mononeuropathy.
Behav Brain Res
; 179(2): 331-5, 2007 May 16.
Article
em En
| MEDLINE
| ID: mdl-17383023
ABSTRACT
The hindpaw withdrawal latencies (HWLs) to noxious thermal and mechanical stimulation increased significantly after intra-hypothalamic arcuate nucleus (ARC) injection of galanin in mononeuropathic rats, while intra-ARC injection of the putative antagonist of galanin receptors markedly reduced the HWLs. The number of galaninergic neurons in the ARC increased in rats with mononeuropathy than that in normal rats. The results demonstrated that both endogenous and exogenous galanin were involved in the regulation of nociception in the ARC of rats with peripheral nerve injury.
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Base de dados:
MEDLINE
Assunto principal:
Tempo de Reação
/
Núcleo Arqueado do Hipotálamo
/
Limiar da Dor
/
Galanina
/
Mononeuropatias
Limite:
Animals
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article