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Discovery of +(2-{4-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethoxy]phenyl}-cyclopropyl)acetic acid as potent and selective alphavbeta3 inhibitor: design, synthesis, and optimization.
Nagarajan, Srinivasan R; Lu, Hwang-Fun; Gasiecki, Alan F; Khanna, Ish K; Parikh, Mihir D; Desai, Bipinchandra N; Rogers, Thomas E; Clare, Michael; Chen, Barbara B; Russell, Mark A; Keene, Jeffery L; Duffin, Tiffany; Engleman, V Wayne; Finn, Mary B; Freeman, Sandra K; Klover, Jon A; Nickols, G Alan; Nickols, Maureen A; Shannon, Kristen E; Steininger, Christina A; Westlin, William F; Westlin, Marisa M; Williams, Melanie L.
Afiliação
  • Nagarajan SR; Pfizer Global Research and Development, St. Louis Laboratories, Pfizer, Inc., 700 Chesterfield Parkway West, Chesterfield, MO 63017, USA. Srinivasan.Nagarajan@Pfizer.com
Bioorg Med Chem ; 15(10): 3390-412, 2007 May 15.
Article em En | MEDLINE | ID: mdl-17387018
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Base de dados: MEDLINE Assunto principal: Integrina alfaVbeta3 / Acetatos / Naftiridinas Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2007 Tipo de documento: Article
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Base de dados: MEDLINE Assunto principal: Integrina alfaVbeta3 / Acetatos / Naftiridinas Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2007 Tipo de documento: Article