The duration of neurotrophic factor independence in early sensory neurons is matched to the time course of target field innervation.
Neuron
; 7(5): 819-30, 1991 Nov.
Article
em En
| MEDLINE
| ID: mdl-1742027
To investigate how the onset of neurotrophic factor dependence in neurons is coordinated with the arrival of their axons in the target field, we have studied the survival of four populations of cranial sensory neurons whose axons reach their common central target field, the hindbrain, at different times. We show that neurons whose axons reach the hindbrain first survive for a short time in culture before responding to brain-derived neurotrophic factor (BDNF). Neurons whose axons reach the hindbrain later survive longer before responding to BDNF. These differences in survival, which arise prior to gangliogenesis, may play a role in coordinating trophic interactions for cranial sensory neurons.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Nervos Cranianos
/
Proteínas do Tecido Nervoso
/
Neurônios Aferentes
Limite:
Animals
Idioma:
En
Ano de publicação:
1991
Tipo de documento:
Article