[Effects of ACE2-Ang 1-7-Mas axis on blood vessel].
Sheng Li Ke Xue Jin Zhan
; 38(1): 43-8, 2007 Jan.
Article
em Zh
| MEDLINE
| ID: mdl-17438952
ABSTRACT
The recent identification of angiotensin-converting enzyme 2 (ACE2) and Mas receptor opened new recognition of renin-angiotensin system (RAS). ACE2, a homologue of angiotensin-converting enzyme (ACE) generates angiotensin 1-7 directly through cleaving angiotensin II, or indirectly through angiotensin I in the body. Ang 1-7 exhibits vasodilatory and antiproliferative effects, and these effects were mainly mediated by Mas receptor. So ACE2-angiotensin1-7- Mas axis was considered a negative regulation in renin angiotensin system (RAS), and its significance has been implicated into hypertension and other cardiovascular diseases. The identification of the axis opens a new potential venue for further study and understanding of RAS.
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Base de dados:
MEDLINE
Assunto principal:
Fragmentos de Peptídeos
/
Sistema Renina-Angiotensina
/
Vasos Sanguíneos
/
Angiotensina I
/
Proteínas Proto-Oncogênicas
/
Peptidil Dipeptidase A
/
Receptores Acoplados a Proteínas G
Limite:
Animals
/
Humans
Idioma:
Zh
Ano de publicação:
2007
Tipo de documento:
Article