Assessment of medial thinning in atherosclerosis by intravascular ultrasound.
Am J Cardiol
; 68(17): 1625-32, 1991 Dec 15.
Article
em En
| MEDLINE
| ID: mdl-1746464
ABSTRACT
This study investigated the in vitro (40 MHz) and in vivo (30 MHz) feasibility of intravascular ultrasound to document the influence of atherosclerotic lesions on the typical 3-layered appearance of muscular arteries. The in vitro images of 39 arteries were compared with the corresponding histologic sections. Media and lesion thickness were measured at the areas of minimal and maximal lesion thickness. The median media thickness was 0.8 mm in the absence of a lesion, decreasing to 0.3 mm in the area of maximal atherosclerosis. The ultrasonic data correlated closely with histologic measurements (0.6 and 0.3 mm, respectively). The in vivo study was performed in 29 patients undergoing coronary or peripheral vascular procedures. A total of 150 still-frames were selected for quantitative analysis. The median media thickness was 0.6 mm in the absence of a lesion, decreasing to 0.1 mm in the area with maximal atherosclerosis. This study revealed that intravascular ultrasound imaging accurately determines that media thickness of muscular arteries is inversely related to lesion thickness. In vitro data, verified with histology, can be translated to humans in vivo.
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Base de dados:
MEDLINE
Assunto principal:
Arteriosclerose
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
1991
Tipo de documento:
Article