Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression.
J Exp Med
; 204(6): 1257-65, 2007 Jun 11.
Article
em En
| MEDLINE
| ID: mdl-17502665
ABSTRACT
The study of T regulatory cells (T reg cells) has been limited by the lack of specific surface markers and an inability to define mechanisms of suppression. We show that the expression of CD39/ENTPD1 in concert with CD73/ecto-5'-nucleotidase distinguishes CD4(+)/CD25(+)/Foxp3(+) T reg cells from other T cells. These ectoenzymes generate pericellular adenosine from extracellular nucleotides. The coordinated expression of CD39/CD73 on T reg cells and the adenosine A2A receptor on activated T effector cells generates immunosuppressive loops, indicating roles in the inhibitory function of T reg cells. Consequently, T reg cells from Cd39-null mice show impaired suppressive properties in vitro and fail to block allograft rejection in vivo. We conclude that CD39 and CD73 are surface markers of T reg cells that impart a specific biochemical signature characterized by adenosine generation that has functional relevance for cellular immunoregulation.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Apirase
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Antígenos CD
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5'-Nucleotidase
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Adenosina
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Terapia de Imunossupressão
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Linfócitos T Reguladores
Limite:
Animals
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article