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Influence of family history of type 2 diabetes on leptin concentration in cord blood of male offspring with high birth weight.
Buongiorno, Angela Maria; Morelli, Stefania; Sagratella, Elisabetta; Sensi, Maurizio; Maroccia, Ettore; Caiola, Stefania; Vasta, Mario.
Afiliação
  • Buongiorno AM; Dipartimento di Ematologia Oncologia e Medicina Molecolare, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy. angela.buongiorno@iss.it
Ann Ist Super Sanita ; 43(1): 77-82, 2007.
Article em En | MEDLINE | ID: mdl-17536157
To verify whether a diabetes family history might be a risk factor for the development, in adult age, of metabolic disorders, leptin, anthropometric and endocrine parameters were analysed in 95 babies with grandparents affected by type 2 diabetes (DF) and in 95 matched babies without diabetes family history (NDF). A sexual dimorphism for leptin was present in the NDF group (males: 6.7+/-4.1 ng/ml; females: 12.3+/-6.5; p < 0.0001) but not in the DF group (males: 9.0+/-5.5; females: 10.8+/-6.4), due to the significant increase in DF male leptin level, compared to that of NDF males (p < 0.05). In DF males only, leptin was positively correlated with body length, PI, C-peptide, IGF-1 and IGF1BP3. These results suggest that the increase in DF male leptin could be a compensatory mechanism for reduced insulin sensitivity in a pre-clinical alteration of glucose metabolism.
Assuntos
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Base de dados: MEDLINE Assunto principal: Peso ao Nascer / Estatura / Leptina / Diabetes Mellitus Tipo 2 / Sangue Fetal Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Female / Humans / Male / Newborn País como assunto: Europa Idioma: En Ano de publicação: 2007 Tipo de documento: Article
Buscar no Google
Base de dados: MEDLINE Assunto principal: Peso ao Nascer / Estatura / Leptina / Diabetes Mellitus Tipo 2 / Sangue Fetal Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Female / Humans / Male / Newborn País como assunto: Europa Idioma: En Ano de publicação: 2007 Tipo de documento: Article