Influence of family history of type 2 diabetes on leptin concentration in cord blood of male offspring with high birth weight.
Ann Ist Super Sanita
; 43(1): 77-82, 2007.
Article
em En
| MEDLINE
| ID: mdl-17536157
To verify whether a diabetes family history might be a risk factor for the development, in adult age, of metabolic disorders, leptin, anthropometric and endocrine parameters were analysed in 95 babies with grandparents affected by type 2 diabetes (DF) and in 95 matched babies without diabetes family history (NDF). A sexual dimorphism for leptin was present in the NDF group (males: 6.7+/-4.1 ng/ml; females: 12.3+/-6.5; p < 0.0001) but not in the DF group (males: 9.0+/-5.5; females: 10.8+/-6.4), due to the significant increase in DF male leptin level, compared to that of NDF males (p < 0.05). In DF males only, leptin was positively correlated with body length, PI, C-peptide, IGF-1 and IGF1BP3. These results suggest that the increase in DF male leptin could be a compensatory mechanism for reduced insulin sensitivity in a pre-clinical alteration of glucose metabolism.
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Base de dados:
MEDLINE
Assunto principal:
Peso ao Nascer
/
Estatura
/
Leptina
/
Diabetes Mellitus Tipo 2
/
Sangue Fetal
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
/
Male
/
Newborn
País como assunto:
Europa
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article