Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility.
Nat Genet
; 39(7): 830-2, 2007 Jul.
Article
em En
| MEDLINE
| ID: mdl-17554261
ABSTRACT
A genome-wide association scan in individuals with Crohn's disease by the Wellcome Trust Case Control Consortium detected strong association at four novel loci. We tested 37 SNPs from these and other loci for association in an independent case-control sample. We obtained replication for the autophagy-inducing IRGM gene on chromosome 5q33.1 (replication P = 6.6 x 10(-4), combined P = 2.1 x 10(-10)) and for nine other loci, including NKX2-3, PTPN2 and gene deserts on chromosomes 1q and 5p13.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Autofagia
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Variação Genética
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Doença de Crohn
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Proteínas de Ligação ao GTP
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Predisposição Genética para Doença
Tipo de estudo:
Observational_studies
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Risk_factors_studies
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article