Synthesis and SAR of novel conformationally restricted oxazolidinones possessing gram-positive and fastidious gram-negative antibacterial activity. Part 2: Amino substitutions on heterocyclic D-ring system.
Bioorg Med Chem Lett
; 17(16): 4699-702, 2007 Aug 15.
Article
em En
| MEDLINE
| ID: mdl-17562363
ABSTRACT
A novel series of conformationally restricted oxazolidinones was synthesized, in which the heterocyclic D ring was substituted with various amino groups. Several analogs exhibited potent activity against both gram-positive and fastidious gram-negative organisms. Certain amino-substituted analogs also exhibited improved aqueous solubility compared to the corresponding un-substituted heterocyclic D-ring analogs.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Oxazolidinonas
/
Antibacterianos
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article