Caenorhabditis elegans SID-2 is required for environmental RNA interference.
Proc Natl Acad Sci U S A
; 104(25): 10565-70, 2007 Jun 19.
Article
em En
| MEDLINE
| ID: mdl-17563372
ABSTRACT
In plants and in the nematode Caenorhabditis elegans, an RNAi signal can trigger gene silencing in cells distant from the site where silencing is initiated. In plants, this signal is known to be a form of dsRNA, and the signal is most likely a form of dsRNA in C. elegans as well. Furthermore, in C. elegans, dsRNA present in the environment or expressed in ingested bacteria is sufficient to trigger RNAi (environmental RNAi). Ingestion and soaking delivery of dsRNA has also been described for other invertebrates. Here we report the identification and characterization of SID-2, an intestinal luminal transmembrane protein required for environmental RNAi in C. elegans. SID-2, when expressed in the environmental RNAi defective species Caenorhabditis briggsae, confers environmental RNAi.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Caenorhabditis elegans
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RNA de Helmintos
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Proteínas de Caenorhabditis elegans
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Interferência de RNA
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Proteínas de Membrana
Limite:
Animals
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article