IL-15 levels in patients with acute hepatic failure.
Res Commun Mol Pathol Pharmacol
; 115-116: 5-14, 2004.
Article
em En
| MEDLINE
| ID: mdl-17564301
ABSTRACT
Interleukin (IL)-15, an inhibitor of tumor necrosis factor (TNF)-alpha, causes liver injury in mice. We determined levels of IL-15, IL-6, and IL-18 by enzyme-linked immunosorbent assays in 20 patients with acute hepatic failure and examined relationship between these proinflammatory cytokines and IL-15. A significant correlation was observed between the levels of IL-18 and IL-15 (p = 0.0118). IL-15 levels in the nonsurvivors were significantly higher than those in the survivors (p = 0.0357). Our results suggest that IL-15 overexpression may cause liver injury in human.
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Base de dados:
MEDLINE
Assunto principal:
Falência Hepática Aguda
/
Interleucina-15
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article