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A covariance structure model for the admixture of binary genetic variation.
Grote, Mark N.
Afiliação
  • Grote MN; Department of Anthropology, University of California-Davis, 1 Shields Avenue, Davis, CA 95616, USA. mngrote@ucdavis.edu
Genetics ; 176(4): 2405-20, 2007 Aug.
Article em En | MEDLINE | ID: mdl-17565951
I derive a covariance structure model for pairwise linkage disequilibrium (LD) between binary markers in a recently admixed population and use a generalized least-squares method to fit the model to two different data sets. Both linked and unlinked marker pairs are incorporated in the model. Under the model, a pairwise LD matrix is decomposed into two component matrices, one containing LD attributable to admixture, and another containing, in an aggregate form, LD specific to the populations forming the mixture. I use population genetics theory to show that the latter matrix has block-diagonal structure. For the data sets considered here, I show that the number of source populations can be determined by statistical inference on the canonical correlations of the sample LD matrix.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Variação Genética / Desequilíbrio de Ligação / Modelos Genéticos Tipo de estudo: Risk_factors_studies Limite: Female / Humans / Male Idioma: En Ano de publicação: 2007 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Variação Genética / Desequilíbrio de Ligação / Modelos Genéticos Tipo de estudo: Risk_factors_studies Limite: Female / Humans / Male Idioma: En Ano de publicação: 2007 Tipo de documento: Article