Synthesis and antibacterial activity of novel oxazolidinones with methylene oxygen- and methylene sulfur-linked substituents at C5-position.

Rudra, Sonali; Sangita, Fnu; Gujrati, Arti; Pandya, Manisha; Bhateja, Pragya; Mathur, Tarun; Singhal, Smita; Rattan, Ashok; Salman, Mohammed; Das, Biswajit

Rudra, Sonali; Sangita, Fnu; Gujrati, Arti; Pandya, Manisha; Bhateja, Pragya; Mathur, Tarun; Singhal, Smita; Rattan, Ashok; Salman, Mohammed; Das, Biswajit.

Afiliação

Rudra S; Department of Medicinal Chemistry, New Drug Discovery Research, Ranbaxy Laboratories Limited, Plot-20, Sector-18, Udyog Vihar, Gurgaon, India. sonali.rudra@ranbaxy.com

Bioorg Med Chem Lett ; 17(17): 4778-83, 2007 Sep 01.

Article em En | MEDLINE | ID: mdl-17618116

ABSTRACT

ABSTRACT

Novel oxazolidinone derivatives of the lead compound RBx 8700, containing methylene oxygen- and methylene sulfur-linked substituents at the C5-position, were synthesized. Antibacterial screening of these compounds against a panel of resistant and susceptible Gram-positive and fastidious Gram-negative bacteria gave compounds 2 and 4 as new antibacterial agents.

Assuntos

Antibacterianos/farmacologia; Química Farmacêutica/métodos; Testes de Sensibilidade Microbiana; Oxazolidinonas/química; Enxofre/química; Acetamidas/química; Desenho de Fármacos; Farmacorresistência Bacteriana; Bactérias Gram-Negativas; Linezolida; Espectrometria de Massas; Meticilina/farmacologia; Modelos Químicos; Piperazina; Piperazinas/química; Temperatura; Tiocarbamatos/química

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Base de dados: MEDLINE Assunto principal: Enxofre / Testes de Sensibilidade Microbiana / Química Farmacêutica / Oxazolidinonas / Antibacterianos Idioma: En Ano de publicação: 2007 Tipo de documento: Article

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