Induction of cytotoxic T cell response against HCA661 positive cancer cells through activation with novel HLA-A *0201 restricted epitopes.
Cancer Lett
; 256(2): 178-85, 2007 Oct 28.
Article
em En
| MEDLINE
| ID: mdl-17624664
ABSTRACT
HCA661 is a cancer-testis (CT) antigen frequently expressed in human hepatocellular carcinoma (HCC). To search for immunogenic peptides of HCA661, bioinformatics analysis and CD8(+) T cell IFN-gamma ELISPOT assay were employed, and two HLA-A *0201 restricted peptides, H110 and H246, were identified. These two HCA661 peptides are naturally processed in dendritic cells (DCs) and when used for DCs loading, they are sufficient to prime autologous CD8(+) T cells to elicit cytotoxic response against HCA661(+) human cancer cells. The HCA661 peptides, H110 and H246, are hence attractive candidates for human cancer immunotherapy.
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Base de dados:
MEDLINE
Assunto principal:
Ativação Linfocitária
/
Linfócitos T Citotóxicos
/
Antígenos HLA-A
/
Antígenos CD
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Moléculas de Adesão Celular Neuronais
/
Epitopos Imunodominantes
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Carcinoma Hepatocelular
/
Proteínas Fetais
/
Neoplasias Hepáticas
Limite:
Humans
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article