Pharmacokinetics and pharmacodynamics of DPC 333 ((2R)-2-((3R)-3-amino-3{4-[2-methyl-4-quinolinyl) methoxy] phenyl}-2-oxopyrrolidinyl)-N-hydroxy-4-methylpentanamide)), a potent and selective inhibitor of tumor necrosis factor alpha-converting enzyme in rodents, dogs, chimpanzees, and humans.
Drug Metab Dispos
; 35(10): 1916-25, 2007 Oct.
Article
em En
| MEDLINE
| ID: mdl-17656469
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Base de dados:
MEDLINE
Assunto principal:
Artrite Experimental
/
Quinolinas
/
Endotoxemia
/
Proteínas ADAM
/
Anti-Inflamatórios
Tipo de estudo:
Clinical_trials
/
Prognostic_studies
Limite:
Adult
/
Animals
/
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article