Cellular senescence: when bad things happen to good cells.
Nat Rev Mol Cell Biol
; 8(9): 729-40, 2007 Sep.
Article
em En
| MEDLINE
| ID: mdl-17667954
ABSTRACT
Cells continually experience stress and damage from exogenous and endogenous sources, and their responses range from complete recovery to cell death. Proliferating cells can initiate an additional response by adopting a state of permanent cell-cycle arrest that is termed cellular senescence. Understanding the causes and consequences of cellular senescence has provided novel insights into how cells react to stress, especially genotoxic stress, and how this cellular response can affect complex organismal processes such as the development of cancer and ageing.
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Base de dados:
MEDLINE
Assunto principal:
Envelhecimento
/
Senescência Celular
/
Neoplasias
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article