CDK-5 regulates the abundance of GLR-1 glutamate receptors in the ventral cord of Caenorhabditis elegans.
Mol Biol Cell
; 18(10): 3883-93, 2007 Oct.
Article
em En
| MEDLINE
| ID: mdl-17671168
ABSTRACT
The proline-directed kinase Cdk5 plays a role in several aspects of neuronal development. Here, we show that CDK-5 activity regulates the abundance of the glutamate receptor GLR-1 in the ventral cord of Caenorhabditis elegans and that it produces corresponding changes in GLR-1-dependent behaviors. Loss of CDK-5 activity results in decreased abundance of GLR-1 in the ventral cord, accompanied by accumulation of GLR-1 in neuronal cell bodies. Genetic analysis of cdk-5 and the clathrin adaptin unc-11 AP180 suggests that CDK-5 functions prior to endocytosis at the synapse. The scaffolding protein LIN-10/Mint-1 also regulates GLR-1 abundance in the nerve cord. CDK-5 phosphorylates LIN-10/Mint-1 in vitro and bidirectionally regulates the abundance of LIN-10/Mint-1 in the ventral cord. We propose that CDK-5 promotes the anterograde trafficking of GLR-1 and that phosphorylation of LIN-10 may play a role in this process.
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Base de dados:
MEDLINE
Assunto principal:
Caenorhabditis elegans
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Receptores de AMPA
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Proteínas de Caenorhabditis elegans
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Quinase 5 Dependente de Ciclina
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Sistema Nervoso
Limite:
Animals
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article