Impact of immigration on the molecular epidemiology of Mycobacterium tuberculosis in a low-incidence country.
Am J Respir Crit Care Med
; 176(9): 930-5, 2007 Nov 01.
Article
em En
| MEDLINE
| ID: mdl-17673698
ABSTRACT
RATIONALE Programs to prevent the incidence rate of tuberculosis (TB) from increasing in many low-incidence countries are challenged by international travel and immigration from high-burden countries. OBJECTIVES:
The current study aimed to determine the effect of such immigration on the genetic diversity of Mycobacterium tuberculosis isolates in an entire nation's population during 1994-2005.METHODS:
A total of 3,131 patients were notified with TB during the 12-year period. Of these, 2,284 (73%) had TB verified by culture, and isolates from 2,173 (96%) of these were analyzed by IS6110 restriction fragment length polymorphism. MEASUREMENTS AND MAINRESULTS:
Only 31% of the included strains were isolated from nonimmigrants, the remaining 69% were isolated from immigrants. Although the incidence increased throughout the period, the genetic diversity remained high. A total of 135 clusters were identified; the percentage of recent disease was reduced among nonimmigrants, and remained stable among the immigrants during the study period. Although 69% of the isolates originated from immigrants from high-incidence countries, the established TB control program in the receiving country was adequate for the prevention of disease transmission. On average per year, only 2 nonimmigrants and 13 immigrants developed disease as a result of infection within the country by imported M. tuberculosis.CONCLUSIONS:
Twelve years of M. tuberculosis importation as a result of immigration from high-incidence countries had little influence on the transmission of this pathogen in the receiving low-incidence country. To prevent future increase of transmission of TB, the current control strategies of low-incidence countries are adequate but must be maintained.
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Base de dados:
MEDLINE
Assunto principal:
Tuberculose
/
Emigração e Imigração
/
Mycobacterium tuberculosis
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
Limite:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Child
/
Child, preschool
/
Humans
/
Infant
/
Middle aged
País como assunto:
Europa
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article