Extramedullary molecular evidence of the 5'KIAA1509/3'PDGFRB fusion gene in chronic eosinophilic leukemia.
Leuk Res
; 32(2): 347-51, 2008 Feb.
Article
em En
| MEDLINE
| ID: mdl-17681599
ABSTRACT
We report a case of chronic eosinophilic leukemia (CEL), demonstrating for the first time (i) the association of CEL with the 5'KIAA1509/3'PDGFRB fusion gene as a consequence of a t(5;14)(q33;q32); (ii) the molecular detection of this rearrangement in an extramedullary site; (iii) the cloning and sequencing of the KIAA1509 and PDGFRB genomic breakpoints. The 5'KIAA1509/3'PDGFRB fusion gene is predicted to encode a protein of 2059 amino acids. The genomic breakpoints were localized inside KIAA1509 intron 11 and PDGFRB intron 10. Sequence analysis in correspondence with these breakpoints revealed the presence of repetitive DNA, such Alu elements, which could promote chromosomal rearrangements.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Síndrome Hipereosinofílica
/
Proteínas Proto-Oncogênicas c-sis
/
Fusão Gênica
Tipo de estudo:
Prognostic_studies
Limite:
Adult
/
Female
/
Humans
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article