AA amyloidosis associated with systemic lupus erythematosus: impact on clinical course and outcome.
Rheumatol Int
; 28(4): 367-70, 2008 Feb.
Article
em En
| MEDLINE
| ID: mdl-17687556
ABSTRACT
Secondary amyloidosis (AA amyloidosis) has rarely been described in patients with systemic lupus erythematosus (SLE). We, herein, present a 56-year-old female patient, who developed AA amyloidosis following a 22-year history of SLE. She developed severe mitral regurgitation complicated with chordae tendinea rupture that led to acute congestive heart failure and went on a mitral valve replacement, where no flare symptoms of SLE were present. Three months after the operation, she presented with a nephrotic-range proteinuria, acute renal failure, and severe sepsis. She was found to have new vegetations on replaced valve and multi-organ failure caused her death. Re-evaluation of the excised mitral valve revealed AA amyloid deposition. Post-mortem biopsies from the kidney and bone marrow also revealed secondary amyloidosis.
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Base de dados:
MEDLINE
Assunto principal:
Choque Séptico
/
Amiloidose
/
Lúpus Eritematoso Sistêmico
/
Insuficiência da Valva Mitral
/
Insuficiência de Múltiplos Órgãos
/
Síndrome Nefrótica
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
/
Middle aged
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article