Alcohol- and substance-dependent subjects: the correlated factors in qualifying for liver transplantation.

ABSTRACT

OBJECTIVES: To identify the most significant variables in determining if candidates with past or current addictions can be considered for liver transplantation. METHODS: Data relating to 58 cases from January 2001 to December 2003 were collected and analyzed. RESULTS: The decisional algorithm identified by discriminant analysis is based on the following variables the duration of remission, treatment adherence, and the presence of a valid help relationship. Candidates undergoing initial remission (up to 12 months) must demonstrate both adherence and affective support; those with over 5 years of remission, however, are considered sufficiently reliable. A positive judgment is significantly correlated to overall survival and clinical improvement even without transplantation. CONCLUSIONS: In toxicological evaluation, treatment adherence and the presence of a valid help relationship for patients in remission from addictions can improve the selection criteria for liver transplantation, making it more dependable.