HIF and c-Myc: sibling rivals for control of cancer cell metabolism and proliferation.
Cancer Cell
; 12(2): 108-13, 2007 Aug.
Article
em En
| MEDLINE
| ID: mdl-17692803
ABSTRACT
O(2) deprivation (hypoxia) and cellular proliferation engage opposite cellular pathways, yet often coexist during tumor growth. The ability of cells to grow during hypoxia results in part from crosstalk between hypoxia-inducible factors (HIFs) and the proto-oncogene c-Myc. Acting alone, HIF and c-Myc partially regulate complex adaptations undertaken by tumor cells growing in low O(2). However, acting in concert these transcription factors reprogram metabolism, protein synthesis, and cell cycle progression, to "fine tune" adaptive responses to hypoxic environments.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Hipóxia Celular
/
Proteínas Proto-Oncogênicas c-myc
/
Proliferação de Células
/
Subunidade alfa do Fator 1 Induzível por Hipóxia
/
Neoplasias
Limite:
Humans
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article