FDG-PET detection of primary bone marrow large B-cell lymphoma in a patient with hairy cell leukemia.
Nucl Med Rev Cent East Eur
; 10(1): 23-5, 2007.
Article
em En
| MEDLINE
| ID: mdl-17694498
ABSTRACT
We describe a case of hairy cell leukaemia (HCL) coexistent with non-Hodgkin's lymphoma (NHD). This combination is reported to be extremely rare with no clear demonstration of the clonal relationship between the two conditions. After a previous failure of purine analogue therapy, our patient was successfully treated with rituximab resulting in normalisation of blood cell count cessation of blood transfusion and negative iliac crest biopsy. Unfortunately, the patient developed intense and persistent bone pain during the 1(st) line treatment for HCL. Skeletal X-rays, neck-thorax-abdomen CT scan and repeated bone MRI were unremarkable and bone scintigraphy showed non-specific changes. Laboratory examinations were normal. To better evaluate bone scintigraphy results, we finally performed FDG-PET/CT, which showed multiple foci of intense abnormal radiotracer uptake involving the bone marrow. An FDG-PET/CT guided bone marrow biopsy showed primary bone marrow diffuse large B-cell lymphoma (LBCL). Despite 2(nd) and 3(rd) line treatment, the patient died shortly after for central nervous system involvement by NHD. The role of FDG-PET/CT in identifying bone and bone marrow localization of NHD is reviewed and an earlier use is suggested in poorly understood bone pain.
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Base de dados:
MEDLINE
Assunto principal:
Radioisótopos de Flúor
/
Leucemia de Células Pilosas
/
Linfoma de Células B
/
Linfoma Difuso de Grandes Células B
/
Compostos Radiofarmacêuticos
/
Fluordesoxiglucose F18
/
Neoplasias Primárias Múltiplas
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Adult
/
Female
/
Humans
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article