Plasma from women with preeclampsia has a low lipid and ketone body content--a nuclear magnetic resonance study.
Hypertens Pregnancy
; 26(3): 329-42, 2007.
Article
em En
| MEDLINE
| ID: mdl-17710581
ABSTRACT
OBJECTIVE:
Using (1)H-nuclear magnetic resonance spectroscopy and chemometrics, we sought to establish the metabolic profile for preeclampsia and to identify biomarkers that would permit a distinction between women with a normal pregnancy and those suffering from preeclampsia.METHODS:
Plasma samples from 11 normotensive pregnant women and 11 women with preeclampsia were analyzed. Principal component analysis was applied to differentiate between the two groups of patients.RESULTS:
Lipid concentrations were found to be significantly lower in the plasma of patients suffering from preeclampsia than those in normotensive pregnant women (p = 0.031). There is also evidence to suggest that ketone body constituents may contribute to the discrimination.CONCLUSION:
(1)H-nuclear magnetic resonance-based metabolic profiling can detect patients with preeclampsia.
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Base de dados:
MEDLINE
Assunto principal:
Pré-Eclâmpsia
/
Espectroscopia de Ressonância Magnética
/
Corpos Cetônicos
/
Lipídeos
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
Limite:
Female
/
Humans
/
Pregnancy
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article