Resistance to viral infection of super p53 mice.
Oncogene
; 24(18): 3059-62, 2005 Apr 21.
Article
em En
| MEDLINE
| ID: mdl-17726827
ABSTRACT
Induction of expression of the tumor suppressor p53 after interferon treatment has been recently demonstrated (Takaoka et al., 2003), suggesting an antiviral activity of the protein. In addition, a direct correlation between p53 levels and tumor resistance has been addressed by generating mice with an extra copy of p53 ('super p53' mice) (Garcia-Cao et al., 2002). Here, we show that vesicular stomatitis virus replication in mouse embryo fibroblasts derived from 'super p53' mice is impaired as a result of apoptosis induction via p53 activation. These findings unequivocally demonstrate an antiviral activity of p53, a process that may contribute to inhibit the spread of the virus in vivo.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Proteína Supressora de Tumor p53
/
Apoptose
/
Infecções por Rhabdoviridae
/
Vírus da Estomatite Vesicular Indiana
Limite:
Animals
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article