Thiazole-diamides as potent gamma-secretase inhibitors.
Bioorg Med Chem Lett
; 17(20): 5518-22, 2007 Oct 15.
Article
em En
| MEDLINE
| ID: mdl-17764937
ABSTRACT
The thiazole-diamide series (1) has been identified as highly potent gamma-secretase inhibitors. Several representative compounds showed IC(50) values of <0.3 nM. The synthesis and SAR, as well as a radiolabeled synthesis of [(3)H]-2a, are described.
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Base de dados:
MEDLINE
Assunto principal:
Tiazóis
/
Diamida
/
Secretases da Proteína Precursora do Amiloide
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article