Phenotypic and functional characterization of ex vivo T cell responses to the live attenuated herpes zoster vaccine.
Vaccine
; 25(41): 7087-93, 2007 Oct 10.
Article
em En
| MEDLINE
| ID: mdl-17766015
ABSTRACT
To define the phenotypic characteristics and kinetics of T cell responses to a shingles vaccine in elderly individuals, 20 subjects > or =60 years of age received two doses of vaccine or placebo 6 weeks apart. VZV-specific T cell phenotypes and intracellular cytokines were determined by flow cytometry on blood mononuclear cells obtained pre-vaccination and up to 6 months after the second immunization. Results were compared with responses of five unvaccinated young adults. Pre-vaccination, elderly individuals had significantly lower VZV-specific effectors and cytokine-producing T cells compared with young adults. The vaccine significantly increased VZV-specific Th1, memory, early effector, and cutaneous homing receptor-bearing T cells.
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Base de dados:
MEDLINE
Assunto principal:
Linfócitos T
/
Subpopulações de Linfócitos T
/
Vacina contra Herpes Zoster
Tipo de estudo:
Clinical_trials
Limite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article