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Metabolic implications of GH treatment in small for gestational age.
Delemarre, E M; Rotteveel, J; Delemarre-van de Waal, H A.
Afiliação
  • Delemarre EM; Medical School Leiden University Medical Center, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands.
Eur J Endocrinol ; 157 Suppl 1: S47-50, 2007 Aug.
Article em En | MEDLINE | ID: mdl-17785697
Fetal growth retardation is associated with decreased postnatal growth, resulting in a lower adult height. In addition, a low birth weight is associated with an increased risk of developing diseases during adulthood, such as insulin resistance, type 2 diabetes mellitus, hypertension, dyslipidemia, and cardiovascular diseases. Children with persistent postnatal growth retardation, i.e., incomplete catch-up growth, can be treated with human GH. The GH/IGF-I axis is involved in the regulation of carbohydrate and lipid metabolism. The question of whether treatment with GH in children born small for gestational age (SGA) has long-term implications with respect to glucose/insulin and lipid metabolism has not been answered yet. In this article, the available data are reviewed.
Assuntos
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Base de dados: MEDLINE Assunto principal: Recém-Nascido Pequeno para a Idade Gestacional / Hormônio do Crescimento Limite: Humans / Newborn Idioma: En Ano de publicação: 2007 Tipo de documento: Article
Buscar no Google
Base de dados: MEDLINE Assunto principal: Recém-Nascido Pequeno para a Idade Gestacional / Hormônio do Crescimento Limite: Humans / Newborn Idioma: En Ano de publicação: 2007 Tipo de documento: Article