Metabolic implications of GH treatment in small for gestational age.
Eur J Endocrinol
; 157 Suppl 1: S47-50, 2007 Aug.
Article
em En
| MEDLINE
| ID: mdl-17785697
Fetal growth retardation is associated with decreased postnatal growth, resulting in a lower adult height. In addition, a low birth weight is associated with an increased risk of developing diseases during adulthood, such as insulin resistance, type 2 diabetes mellitus, hypertension, dyslipidemia, and cardiovascular diseases. Children with persistent postnatal growth retardation, i.e., incomplete catch-up growth, can be treated with human GH. The GH/IGF-I axis is involved in the regulation of carbohydrate and lipid metabolism. The question of whether treatment with GH in children born small for gestational age (SGA) has long-term implications with respect to glucose/insulin and lipid metabolism has not been answered yet. In this article, the available data are reviewed.
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Base de dados:
MEDLINE
Assunto principal:
Recém-Nascido Pequeno para a Idade Gestacional
/
Hormônio do Crescimento
Limite:
Humans
/
Newborn
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article