Anxiogenic behavior in rats during acute and protracted ethanol withdrawal: reversal by buspirone.
Alcohol
; 8(6): 467-71, 1991.
Article
em En
| MEDLINE
| ID: mdl-1781924
ABSTRACT
This study investigated the effectiveness of buspirone in reversing the anxiogenic behaviors occurring during ethanol withdrawal as measured in the elevated plus-maze. In response to anxiogenic drugs, rats spend less time in and make fewer entries onto the open arms of an elevated plus-maze, whereas anxiolytic drugs produce opposite effects. In this study, rats were fed a liquid diet containing 4.5% ethanol for 7 days. Twelve h (acute withdrawal) and 7 days (protracted withdrawal) following cessation of the ethanol diet, rats were tested on the elevated plus-maze. During these withdrawal periods, the percent open-arm entries and time spent on the open arms were significantly reduced relative to animals fed an ethanol-free diet, suggestive of anxiogenic-like symptoms. Buspirone (0.32-1.25 mg/kg) dose dependently reversed the withdrawal-induced decreases in open-arm activity. The anxiolytic-like activity of buspirone observed during ethanol withdrawal may be due to a reduction in serotonergic neurotransmission through activation of presynaptic 5-HT1A autoreceptors. The results obtained in this study suggest that pharmacotherapy with selective 5-HT1A agonists may be beneficial in alleviation of anxiety during ethanol withdrawal.
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Base de dados:
MEDLINE
Assunto principal:
Ansiedade
/
Síndrome de Abstinência a Substâncias
/
Comportamento Animal
/
Buspirona
/
Etanol
Limite:
Animals
Idioma:
En
Ano de publicação:
1991
Tipo de documento:
Article