Your browser doesn't support javascript.
loading
Preparation and in vitro anti-staphylococcal activity of novel 11-deoxy-11-hydroxyiminorifamycins.
Li, Jing; Ma, Zhenkun; Chapo, Katrina; Yan, Dalai; Lynch, A Simon; Ding, Charles Z.
Afiliação
  • Li J; Department of Medicinal Chemistry, Cumbre Pharmaceuticals Inc., 1502 Viceroy Drive, Dallas, TX 75235, USA.
Bioorg Med Chem Lett ; 17(20): 5510-3, 2007 Oct 15.
Article em En | MEDLINE | ID: mdl-17826091
We report herein the preparation and anti-staphylococcal activity of a series of novel 11-deoxy-11-hydroxyiminorifamycins. Many of the compounds synthesized exhibit potent activity against wild-type Staphylococcus aureus with MICs equivalent to, or better than, rifamycin reference agents. In addition, some of the compounds retain potent activity against an intermediate rifamycin-resistant strain of Staphylococcus aureus. For instance, compound 5k exhibits an MIC of 0.12 microg/mL against an intermediate rifamycin-resistant strain, while the rifamycin reference agents, rifampin and rifalazil, exhibit MICs of 16 microg/mL and 2 microg/mL, respectively, against the same strain.
Assuntos
Buscar no Google
Base de dados: MEDLINE Assunto principal: Oxigênio / Rifamicinas / Staphylococcus aureus / Iminas / Antibacterianos Idioma: En Ano de publicação: 2007 Tipo de documento: Article
Buscar no Google
Base de dados: MEDLINE Assunto principal: Oxigênio / Rifamicinas / Staphylococcus aureus / Iminas / Antibacterianos Idioma: En Ano de publicação: 2007 Tipo de documento: Article