FUS expression alters the differentiation response to all-trans retinoic acid in NB4 and NB4R2 cells.
Br J Haematol
; 139(1): 94-7, 2007 Oct.
Article
em En
| MEDLINE
| ID: mdl-17854312
ABSTRACT
The FUS gene is overexpressed in acute myeloid leukaemia (AML) patients and has roles in transcription and mRNA processing. We used ectopic expression of FUS and FUS antisense sequences to assess the effect of modulation of FUS expression in all-trans retinoic acid (ATRA)-sensitive (NB4) and insensitive (NB4R2) human acute promyelocytic (APL) cell lines which express the t(1517) translocation. Growth, viability and differentiation patterns were maintained, but the expression of the FUS antisense construct in both the cell lines altered the response to ATRA the previously ATRA-sensitive NB4 cells exhibited resistance; whilst the previously resistant NB4R2 cells showed a differentiation response to treatment.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Tretinoína
/
Leucemia Promielocítica Aguda
/
Resistencia a Medicamentos Antineoplásicos
/
Proteína FUS de Ligação a RNA
Limite:
Humans
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article