Treatment of infantile spasms with intravenous gamma-globulins.
Brain Dev
; 13(5): 313-9, 1991 Sep.
Article
em En
| MEDLINE
| ID: mdl-1785653
ABSTRACT
In a prospective study, 23 children with infantile spasms received intravenous gammaglobulins in high doses. 19 patients present a West syndrome. 4 older patients were included in the study because infantile spasms had preceded their Lennox-Gastaut syndrome. None of the patients had recently undergone corticosteroid therapy. No effect was observed in 15 patients, while transitory clinical and/or electroencephalographic improvement was noted in 3. Complete normalization was obtained in the remaining 5 patients, of whom 4 had severe brain lesions. No correlation existed between the therapeutic results and immunological abnormalities, a deficiency in IgG subclasses in particular. On the whole, the therapeutic results were disappointing. But the existence of some cases in which spectacular electroencephalographic and/or clinical improvement was obtained leads us to suggest that IV gamma-globulins be used as auxiliary treatment in infantile spasms.
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Base de dados:
MEDLINE
Assunto principal:
Espasmos Infantis
/
Imunização Passiva
Tipo de estudo:
Observational_studies
Limite:
Humans
/
Infant
Idioma:
En
Ano de publicação:
1991
Tipo de documento:
Article