Human papillomavirus 16 E6, L1, L2 and E2 gene variants in cervical lesion progression.
Virus Res
; 131(1): 106-10, 2008 Jan.
Article
em En
| MEDLINE
| ID: mdl-17869365
ABSTRACT
The human papillomavirus (HPV) 16 E6 genome variant 350G has been found to be more prevalent in women with persistent infection and cervical disease progression than the HPV16 E6 prototype 350T. In this study, we examined whether women who progressed to a high-grade lesion, yet were infected with the prototype 350T, showed variants in other HPV genes such as L1, L2 and E2. Although we detected variants within these genes, they could not explain this phenomenon. Indeed they correlated similarly with variant 350G and prototype 350T. These data indicate that polymorphisms in HPV16 E6 rather than in the other analyzed genes play a role in determining the risk for cervical lesion progression and that additional factors are likely to be required as well.
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Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
/
Proteínas Repressoras
/
Neoplasias do Colo do Útero
/
Proteínas Oncogênicas Virais
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Infecções por Papillomavirus
/
Papillomavirus Humano 16
Limite:
Female
/
Humans
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article