Synthesis and brain antihypoxic activity of some aliphatic and arylaliphatic amides of caffeine-8-thioglycolic acid.
Acta Pharm
; 57(3): 361-70, 2007 Sep.
Article
em En
| MEDLINE
| ID: mdl-17878115
ABSTRACT
The synthesis of some aliphatic and arylaliphatic amides of caffeine-8-thioglycolic acid was studied. The structures of synthesized compounds were proved by micro-analyses, IR- and 1H NMR data. Values of acute p.o. and i.p. toxicity in mice show lower toxicity compared to caffeine. Declines in spontaneous locomotor activity support the idea of depressive CNS activity of the compounds. Two compounds exhibited brain antihypoxic activity (5a and 5b against haemic and circulatory hypoxia, respectively).
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Base de dados:
MEDLINE
Assunto principal:
Tioglicolatos
/
Cafeína
/
Hipóxia-Isquemia Encefálica
Limite:
Animals
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article