[Various quantities of sunflower seed oil in the diet, long-term administration of hydrocortisone and liver tissue lipids in rats]. / Razlicite kolicine suncokretovog ulja u ishrani, dugotrajna primena hidrokoritzona i lipidi tkiva jetre pacova.

ABSTRACT

The influence of different quantities of vegetable oil/sunflower oil/and the long-term ingestion of hydrocortisone on the total lipid content of the liver in rats and cholesterol was studied. The rats were of Wistar strain, males, 2 months old at the beginning of the experiment. The sunflower oil comprised 5 g%/diet A/ and 20 g%/diet B/ in the diet of rats. Two groups of animals were on diet A or B and took as much water as required. Another two experimental groups were on similar diets A or B, with an additional ingestion of 0.5 mg/kg of hydrocortisone natrium-succinate over the whole period of experiment. The experiment lasted 6 months. The study showed that the major participation of the sunflower oil/20 g%/ induced the increase of the total lipid content of the liver, with significant increase of cholesterol. Long-term ingestion of glucocorticosteroids/hydrocortisone natrium-succinate/induced the significant increase of the content of total lipids and cholesterol in the liver tissue in rats, independent of ingestion of sunflower oil in diet.