Assignment of absolute configuration on the basis of the conformational effects induced by chiral derivatizing agents: the 2-arylpyrrolidine case.
Org Lett
; 9(21): 4123-6, 2007 Oct 11.
Article
em En
| MEDLINE
| ID: mdl-17887687
ABSTRACT
A novel approach for determining the absolute configuration of a chiral compound is proposed. The methodology is based on the distinct conformational effects imposed on a chiral substrate by each enantiomer of a chiral derivatizing agent. As a proof of concept, it is shown that the absolute configuration of 2-arylpyrrolidines can easily be determined by inspection of the multiplicity of the NMR signal of the methine proton of the pyrrolidine ring in the corresponding Mosher's amides.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Pirrolidinas
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article