Novel phospholipase-resistant lipid/peptide synthetic lung surfactants.
Mini Rev Med Chem
; 7(9): 932-44, 2007 Sep.
Article
em En
| MEDLINE
| ID: mdl-17897082
ABSTRACT
Animal-derived drugs are currently widely-used to treat clinical lung surfactant deficiency, but synthetic surfactants have significant advantages as pharmaceutical agents. This article examines exogenous surfactants containing novel synthetic phospholipase-resistant lipids of extremely high surface activity. Mixtures of these lipid analogs with purified native surfactant apoproteins are detailed as a proof of concept for related fully-synthetic surfactants containing laboratory-produced peptides. The chemistry and biophysics of relevant lipid analogs and peptides are reviewed in the context of developing new synthetic drugs of utility for patients with surfactant deficiency or lung injury-related surfactant dysfunction.
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Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Fosfolipases
/
Fosfolipídeos
/
Surfactantes Pulmonares
Limite:
Humans
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article