DNA repair polymorphisms XRCC1 and MGMT and risk of adult gliomas.
Neuroepidemiology
; 29(1-2): 55-8, 2007.
Article
em En
| MEDLINE
| ID: mdl-17898525
ABSTRACT
X-ray cross complementing group 1 (XRCC1) and O6-methylguanine-DNA methyltransferase (MGMT) are pivotal repair genes focused on repairing lesions due to ionizing radiation, alkylating agents, and oxidative DNA damage, risk factors previously linked to gliomas. Using the population based San Francisco Adult Glioma study, we evaluated associations between XRCC1 Arg399Gln, MGMT Leu84Phe, and MGMT Ile143Val polymorphisms with glioma risk among white cases (n = 441 to 453) and controls (n = 487 to 526). We found no evidence of an association between XRCC1 genotypes and glioma. We observed a weak positive association for the MGMT Leu84Phe polymorphism (Leu or Phe/Phe versus Leu/Leu adjusted OR = 1.26; CI 0.90-1.75) and the MGMT Ile143Val polymorphism (Ile or Val/Val versus Ile/Ile adjusted OR = 1.20; CI 0.85-1.71).
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Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
/
Neoplasias Encefálicas
/
Metilases de Modificação do DNA
/
Proteínas Supressoras de Tumor
/
Enzimas Reparadoras do DNA
/
Proteínas de Ligação a DNA
/
Glioma
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
País como assunto:
America do norte
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article