Hepatitis C virus activation in HIV-infected patients initiating highly active antiretroviral therapy.
AIDS Patient Care STDS
; 21(10): 718-23, 2007 Oct.
Article
em En
| MEDLINE
| ID: mdl-17949270
ABSTRACT
We describe repeated episodes of hepatitis C (HCV) activation associated with initiation of highly active antiretroviral therapy (HAART) in two HIV/HCV coinfected individuals with undetectable serum HCV RNA. Both patients developed high HCV viremia (>1 million IU/mL) and elevations in aminotransferases >10 times upper limit of normal) within 4 months of starting HAART. This is the first report of clinically significant HCV activation in HCV-seropositive patients with initially undetectable HCV viremia. These observations suggest that flares of hepatitis C in the setting of the immune reconstitution inflammatory syndrome can occur even in those patients who have undetectable serum HCV levels prior to HAART initiation.
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Base de dados:
MEDLINE
Assunto principal:
Ativação Viral
/
Infecções por HIV
/
Hepatite C
/
Hepacivirus
/
Fármacos Anti-HIV
/
Terapia Antirretroviral de Alta Atividade
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article