The involvement of the polyamines binding sites at the NMDA receptor in creatine-induced spatial learning enhancement.
Behav Brain Res
; 187(1): 200-4, 2008 Feb 11.
Article
em En
| MEDLINE
| ID: mdl-17950476
ABSTRACT
Achievements made over the last years have highlighted the important role of creatine in health and disease. However, studies of its effect on cognition function have been limited. In the present study, we investigated the effect of creatine on early consolidation of the spatial learning in rats. Statistical analysis showed that intrahippocampal administration of creatine (2.5 and 7.5 nmol/hippocampus) (post-training) decreased the latency for scape and mean number of errors in Barnes maze test. The involvement of polyamine binding site at NMDA receptor in creatine-induced spatial learning enhancement was investigated by co-administration of arcaine (0.02 nmol/hippocampus) or spermidine (0.02 nmol/hippocampus) with creatine (2.5 nmol/hippocampus) (post-training). Statistical analysis revealed that creatine-induced spatial learning enhancement was reverted by co-administration of arcaine (0.02 nmol/hippocampus) and intensified by spermidine (0.02 nmol/hippocampus). These results provide evidence that creatine not only seem to be involved in energy metabolism but may also play an important role in early consolidation of spatial learning in hippocampus which participation of polyamines binding site at the NMDA receptor.
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Base de dados:
MEDLINE
Assunto principal:
Poliaminas
/
Percepção Espacial
/
Receptores de N-Metil-D-Aspartato
/
Aprendizagem em Labirinto
/
Creatina
Limite:
Animals
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article