[A comparative study of Gd-DTPA and HSA-Gd-DTPA in magnetic resonance lymphography].
Nan Fang Yi Ke Da Xue Xue Bao
; 27(10): 1597-600, 2007 Oct.
Article
em Zh
| MEDLINE
| ID: mdl-17959548
ABSTRACT
OBJECTIVE:
To compare the effects of two contrast agents, Gd-DTPA and HSA-Gd-DTPA, in magnetic resonance (MR) lymphography.METHODS:
Twelve New-Zealand rabbits were randomized into Gd-DTPA and HSA-Gd-DTPA groups with subcutaneous (interdigital skin fold) injection of the two contrast agents (0.2 ml of 0.5 mmol/L Gd(3+)) for MR lymphography of the popliteal lymph nodes examined in the axial and sagital orientation. T(1)-weighted, T1-weighted fat suppressed, and T(2)-weighted spin-echo (SE) images of the lymph nodes were obtained in plain scans. The post-contrast scanning started at 30 min, 1 h and 3 h after Gd-DTPA administration and at 10 min, 30 min and 60 min after HSA-Gd-DTPA injection to obtain T(1)-weighted images with identical imaging parameters. The signal intensity of popliteal lymph node was measured and the enhancement rate calculated.RESULTS:
After subcutaneous injection, Gd-DTPA quickly entered blood circulation to result in obvious enhancement of the anterior-tibial vein and the urine and also in heterogeneous enhancement of the popliteal lymph nodes. HSA-Gd-DTPA did not enter the blood, causing obvious homogeneous enhancement of the lymphatic vessels and lymph nodes. HSA-Gd-DTPA resulted in higher enhancement rate than Gd-DTPA, and the enhancement rate in Gd-DTPA group decreased with time as opposed to that of the HSA-Gd-DTPA group.CONCLUSION:
HSA-Gd-DTPA has better performance than Gd-DTPA in MR lymphography after subcutaneous administration.
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Base de dados:
MEDLINE
Assunto principal:
Albumina Sérica
/
Linfografia
/
Meios de Contraste
/
Gadolínio DTPA
/
Linfonodos
Tipo de estudo:
Clinical_trials
Limite:
Animals
/
Humans
Idioma:
Zh
Ano de publicação:
2007
Tipo de documento:
Article