Quaternary ammonium chitosan derivative dynamic coating for the separation of veterinary sulfonamide residues by CE with field-amplified sample injection.
Electrophoresis
; 28(22): 4091-100, 2007 Nov.
Article
em En
| MEDLINE
| ID: mdl-17960537
ABSTRACT
A quaternary ammonium chitosan, 2-hydroxypropyltrimethylammonium chloride chitosan (HACC), has been developed for the dynamic coating material in CE for the first time. It presented many advantages such as favorable water solubility, satisfactory coating efficiency, and EOF toward the anode at pH >7.0. Using the modified fused-silica capillary, sulfonamides (SAs), an important group of veterinary drugs, were separated and detected by CE combined with field-amplified sample injection (FASI). The LODs of sulfonamides with UV detection were less than 0.5 ng/mL. The proposed method has been applied to the determination of veterinary sulfonamide residues in samples such as chicken, beef, and honey with fast separation (15 sulfonamides within 20 min), low LODs (0.1-0.5 ng/mL), and good reliability compared to the criteria of China (GB/T 18932.17-2003).
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Base de dados:
MEDLINE
Assunto principal:
Sulfonamidas
/
Eletroforese Capilar
/
Drogas Veterinárias
/
Quitosana
Limite:
Animals
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article