The effect of saline solutions on nasal patency and mucociliary clearance in rhinosinusitis patients.
Otolaryngol Head Neck Surg
; 137(5): 815-21, 2007 Nov.
Article
em En
| MEDLINE
| ID: mdl-17967652
ABSTRACT
OBJECTIVE:
To compare the effect of two saline nasal sprays on nasal patency and mucociliary clearance in patients with rhinosinusitis. STUDYDESIGN:
Randomized double-blind trial. SUBJECTS ANDMETHODS:
Eighty patients with rhinosinusitis at a tertiary care academic center had nasal patency and mucociliary clearance measured. Each patient was then treated with either physiological or hypertonic saline. Nasal patency and mucociliary clearance measurements were repeated after treatment. Subjective evaluation was also performed.RESULTS:
Both solutions improved saccharine clearance times (P < 0.0001). Buffered physiological saline significantly affected nasal airway patency (P = 0.006). Both solutions improved symptoms of nasal stuffiness (P < 0.0001) and nasal obstruction (P < 0.0001). Buffered hypertonic saline caused increased nasal burning/irritation compared with buffered physiological saline (P < 0.0001).CONCLUSIONS:
Buffered physiological and buffered hypertonic saline nasal sprays both improve mucociliary clearance, which is beneficial for treatment of rhinosinusitis. Additionally, buffered physiological saline improves nasal airway patency, whereas buffered hypertonic saline has no effect. Both solutions provide symptomatic relief, but buffered hypertonic saline is more irritating.
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Base de dados:
MEDLINE
Assunto principal:
Solução Salina Hipertônica
/
Sinusite
/
Cloreto de Sódio
/
Depuração Mucociliar
/
Cavidade Nasal
Tipo de estudo:
Clinical_trials
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article