Study of an ovarian sclerosing stromal tumor presenting as vaginal bleeding in a 7-month-old.
Pediatr Dev Pathol
; 11(4): 300-4, 2008.
Article
em En
| MEDLINE
| ID: mdl-17990931
ABSTRACT
This communication describes the histological, immunohistochemical, ultrastructural, and cytogenetic study of an ovarian sclerosing stromal tumor resected from a 7-month-old girl who presented with vaginal bleeding. The tumor is very rare, its pathogenesis is not clear, and its hormonal activity has been subject to debate. In addition, it has been rarely seen in children and never in infants, with the youngest patient reported being 10 years of age. Histological study of the tumor showed a process of multinodular asynchronous growth followed by gradual loss of cells, hyalinization, and eventual transformation into corpora albicantia-like structures, thus indicating that the process may be more akin to an ovarian nodular follicular hyperplasia than to a classical neoplasm. The study also documented an elevated proliferative MIB-1 index in the process, which had not been investigated in earlier reports, and illustrated the immunohistochemical reactivity of some of its stromal cells to progesterone receptors.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Ovarianas
/
Hemorragia Uterina
/
Células Estromais
/
Tumores do Estroma Gonadal e dos Cordões Sexuais
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
Limite:
Female
/
Humans
/
Infant
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article