Homeostatic regulation of MeCP2 expression by a CREB-induced microRNA.
Nat Neurosci
; 10(12): 1513-4, 2007 Dec.
Article
em En
| MEDLINE
| ID: mdl-17994015
ABSTRACT
Both increases and decreases in methyl CpG-binding protein 2 (MeCP2) levels cause neurodevelopmental defects. We found that MeCP2 translation is regulated by microRNA 132 (miR132). Block of miR132-mediated repression increased MeCP2 and brain-derived neurotrophic factor (BDNF) levels in cultured rat neurons and the loss of MeCP2 reduced BDNF and miR132 levels in vivo. This feedback loop may provide a mechanism for homeostatic control of MeCP2 expression.
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Base de dados:
MEDLINE
Assunto principal:
Regulação da Expressão Gênica no Desenvolvimento
/
MicroRNAs
/
Proteína de Ligação a CREB
/
Proteína 2 de Ligação a Metil-CpG
Limite:
Animals
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article