Inhibitors of osteoclast differentiation from Cephalotaxus koreana.
J Nat Prod
; 70(12): 2029-32, 2007 Dec.
Article
em En
| MEDLINE
| ID: mdl-17994703
ABSTRACT
Three new flavonoid glycosides ( 1- 3), 11-hydroxyhainanolidol ( 4), and a new dibenzylbutyrolactone lignan glycoside ( 5) were isolated from the aerial parts of Cephalotaxus koreana Nakai, along with 19 known flavonoids. The structures of the new compounds were elucidated using spectroscopic evidence, primarily NMR and MS. Twenty-four compounds were isolated, and among these isoscutellarein 5-O-beta-D-glucopyranoside ( 3), apigenin ( 6), kaempferol 3-O-alpha-L-rhamnopyranosyl(1'''-->6'')-beta-D-glucopyranoside ( 7), tamarixetin 3-O-alpha-L-rhamnopyranosyl(1'''-->6'')-beta-D-glucopyranoside ( 8), quercetin 3-O-[6''-O-acetyl]-beta-D-glucopyranoside ( 9), and quercetin 3-O-alpha-L-rhamnopyranoside ( 10) showed significant inhibitory activities against osteoclast differentiation at concentrations of 0.1 and 1.0 microg/mL.
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Base de dados:
MEDLINE
Assunto principal:
Osteoclastos
/
Plantas Medicinais
/
Flavonoides
/
Diferenciação Celular
/
Cephalotaxus
/
Glucosídeos
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article