Synthetic hydrogenases: incorporation of an iron carbonyl thiolate into a designed peptide.
J Am Chem Soc
; 129(48): 14844-5, 2007 Dec 05.
Article
em En
| MEDLINE
| ID: mdl-17997557
ABSTRACT
[FeFe] hydrogenases catalyze reversible hydrogen oxidation at an unusual organometallic active site. Neither enzymatic studies nor synthesis of small molecule models has managed to elucidate the mechanisms of these enzymes. In this paper, we demonstrate the incorporation of an iron carbonyl thiolate mimic of the hydrogenase active site into a de novo artificial peptide, creating the first peptide-based model system for hydrogenases.
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Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Hidrogenase
/
Metaloproteínas
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article